Genética, Genómica y COVID-19: implicaciones éticas
Keywords:
genética, genómica, hospedero, COVID-19, éticaAbstract
Introducción:
La genética y la genómica contribuyen al desarrollo de enfoques personalizados y más efectivos para la prevención y el tratamiento de enfermedades infecciosas. Durante la actual pandemia se realizan estudios genómicos a pacientes con COVID-19 o expuestos no afectados, para delinear los factores del huésped asociados con la variabilidad en la susceptibilidad, la infectividad y gravedad de la enfermedad.
Objetivo:
Describir las implicaciones éticas de la genética y genómica en la práctica clínica y la salud pública durante la pandemia de la COVID-19.
Métodos:
Se consultan las bases bibliográficas de PubMed/Medline y Google académico. Se describen las implicaciones éticas, beneficios y perjuicios relacionados con los estudios genéticos y genómicos, en la práctica clínica y la salud pública en la COVID-19.
Conclusiones:
Los estudios genéticos y genómicos desarrollados durante la pandemia de COVID-19 representan un logro de la coordinación y cooperación global.
Downloads
References
Organización Mundial de la Salud. Coronavirus Disease (COVID-19) Dashboard. Data last updated: 2020/11/27 [Internet]. Ginebra: OMS; 2020 [citado 27 nov 2020]. Disponible en: https://covid19.who.int/
Ministerio de Salud Pública de Cuba. Informe epidemiológico COVID-19, 27/11/2020. [citado 27 nov 2020]. Disponible en: https://salud.msp.gob.cu/
Liu Y, Häussinger L, Steinacker JM, Dinse-Lambracht A. Association between the dynamics of the COVID-19 epidemic and ABO blood type distribution. Epidemiol Infect[Internet]. 2021 Jan 7[citado 13 Dic 2021];149:e19. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844181/
American Association for the Advancement of Science[Internet]. Washington, DC: American Association for the Advancement of Science; © 2021. How sick will the coronavirus make you? The answer may be in your genes. [citado 13 Dic 2021]. Disponible en: https://www.science.org/content/article/how-sick-will-coronavirus-make-you-answer-may-be-your-genes
Genetics Initiative . The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. Eur J Hum Genet[Internet]. 2020[citado 13 Dic 2021];28(6):715–8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220587/
Solomon I, Harrington E, Hooker G, Erby L, Axilbund J, Hampel H, et al. Lynch syndrome limbo: patient understanding of variants of uncertain significance. J Genet Couns[Internet]. 2017[citado 13 Dic 2021];26(4):866–77. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1007/s10897-017-0066-y
Brabbing Goldstein D, Reches A, Svirsky R, Bar Shira A, Yaron Y. Dilemmas in genetic counseling for low-penetrance neuro-susceptibility loci detected on prenatal chromosomal microarray analysis. Am J Obstet Gynecol[Internet]. 2018[citado 13 Dic 2021];218(2): 247.e1-247.e12. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0002937817323244?via%3Dihub
Brothers KB, Rothstein MA. Ethical, legal and social implications of incorporating personalized medicine into healthcare. Per Med[Internet]. 2015[citado 13 Dic 2021];12(1):43-51. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296905/
Boyce AM, Garibaldi BT. Genomics and high-consequence infectious diseases: a scoping review of emerging science and potential ethical issues. Health Secur[Internet]. 2019 Jan/Feb[citado 13 Dic 2021];17(1):62-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424158/
Walker A, Boyce A, Duggal P, Thio CL, Geller G. Genomics and infectious diseases: expert perspectives on public health considerations regarding actionability and privacy. Ethics Hum Res[Internet]. 2020 May[citado 13 Dic 2021];42(3):30-40. Disponible en: https://onlinelibrary.wiley.com/doi/epdf/10.1002/eahr.500051
Kuo C-L, Pilling LC, Atkins JL, Masoli J, Delgado J, Kuchel GA,et al. APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort. J Gerontol A Biol Sci Med Sci[Internet]. 2020[citado 13 Dic 2021]; 75(11): 2231–2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314139/pdf/glaa131.pdf
Sirugo G, Williams SM, Tishkoff SA. The missing diversity in human genetic studies. Cell[Internet]. 2019[citado 13 Dic 2021];177(1):26–31. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380073/
Mills MC, Rahal C. The GWAS Diversity Monitor tracks diversity by disease in real time. Nat Genet[Internet]. 2020[citado 13 Dic 2021];52(3):242–3. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/32139905
Milne R. Societal considerations in host genome testing for COVID-19. Genet Med[Internet]. 2020[citado 13 Dic 2021]; 22:1464–6. Disponible en: https://www.nature.com/articles/s41436-020-0861-y.pdf
Greninger AL. Societal implications of the internet of pathogens. J Clin Microbiol[Internet]. 2019[citado 13 Dic 2021];57(6):e01914–e18. Disponible en: https://journals.asm.org/doi/epub/10.1128/JCM.01914-18
Walker A, Boyce A, Geller G, Thio CL, Kahn JP. Direct-acting antivirals and hepatitis C: the ethics of price and rationing by genotype. Clin Infect Dis[Internet]. 2018[citado 13 Dic 2021];67(6):983–4. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190899/
US Equal Employment Opportunity Commission[Internet]. Washington, DC: US Equal Employment Opportunity Commission; c2020. What you should know about COVID-19 and the ADA, the Rehabilitation Act, and other EEO laws. [citado 13 Dic 2021]. Disponible en: https://www.eeoc.gov/wysk/what-you-should-know-about-covid-19-and-ada-rehabilitation-act-and-other-eeo-laws
Bentley AR, Callier SL, Rotimi CN. Evaluating the promise of inclusion of African ancestry populations in genomics. npj Genom Med[Internet]. 2020[citado 13 Dic 2021];5(5):1–9. Disponible en: https://www.nature.com/articles/s41525-019-0111-x.pdf
Valdés Fernández BN, Duconge J, Espino AM, Ruaño G. Personalized health and the coronavirus vaccines-Do individual genetics matter? Bioessays[Internet]. 2021 Sep[citado 13 Dic 2021];43(9):e2100087. Disponible en: https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202100087
Molster CM, Bowman FL, Bilkey GA, Cho AS, Burns BL, Nowak KJ, Dawkins HJS. The Evolution of Public Health Genomics: Exploring Its Past, Present, and Future. Front Public Health[Internet]. 2018 Sep 4[citado 13 Dic 2021];6:247. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131666/
Lantos JD. Ethical and Psychosocial Issues in Whole Genome Sequencing (WGS) for Newborns. Pediatrics[Internet]. 2019 Jan[citado 13 Dic 2021];143(Suppl 1):S1-S5.Disponible en: https://publications.aap.org/pediatrics/article/143/Supplement_1/S1/34201/Ethical-and-Psychosocial-Issues-in-Whole-Genome
Mackley MP, Fletcher B, Parker M, Watkins H, Ormondroyd E. Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies. Genet Med[Internet]. 2017 Mar[citado 13 Dic 2021];19(3):283-93.Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447864/pdf/gim2016109a.pdf
Martinez-Martin N, Magnus D. Privacy and ethical challenges in next-generation sequencing. Expert Rev Precis Med Drug Dev[Internet]. 2019[citado 13 Dic 2021];4(2):95-104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413244/
Kost RG, Poppel SM, Coller BS. Informed consent for next-generation nucleotide sequencing studies: Aiding communication between participants and investigators. J Clin Transl Sci[Internet]. 2017 Apr[citado 13 Dic 2021];1(2):115-120. Disponible en: https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/informed-consent-for-nextgeneration-nucleotide-sequencing-studies-aiding-communication-between-participants-and-investigators/2B0293050882D3F0A240726367293B13
Marchant G, Barnes M, Evans JP, LeRoy B, Wolf SM, Law Seq Liability Task Force. From genetics to genomics: facing the liability implications in clinical care. J Law Med Ethics[Internet]. 2020 Mar;48(1):11-43. Disponible en: https://journals.sagepub.com/doi/full/10.1177/1073110520916994
Coller BS. Ethics of human genome editing. Annu Rev Med[Internet]. 2019 Jan 27;70:289-305. Disponible en: https://doi:10.1146/annurev-med-112717-094629
Geller G, Duggal P, Thio CL, Mathews D, Kahn JP, Maragakis LL, et al. Genomics in the era of COVID-19: ethical implications for clinical practice and public health. Genome Med[Internet]. 2020 Nov[citado 25 Abr 2021];12(1):95. Disponible en: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00792-9
Kumar S, Jha S, Rai SK. Significance of super spreader events in COVID-19. Indian J Public Health[Internet]. 2020 Jun[citado 25 Abr 2021]; 64(Suppl 2):S139-S141. Disponible en: https://www.ijph.in/temp/IndianJPublicHealth646139-6531668_180836.pdf
Rotimi CN, Marshall PA. Tailoring the process of informed consent in genetic and genomic research. Genome Med[Internet]. 2010 [citado 25 Abr 2021];2:20. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873798/
Fariñas Acosta L. Cuba en busca del riesgo genético ante la COVID-19 [Internet]. Cubadebate. La Habana: UCI; © 2014 [actualizado 3 Nov 2020; citado 25 Abr 2021]. Disponible en: http://www.cubadebate.cu/especiales/2020/11/03/cuba-en-busca-del-riesgo-genetico-ante-la-covid-19/
Downloads
Published
How to Cite
Issue
Section
License
Medimay protects copyright from the very first moment the submission is made, but upon publication it assumes a Creative Commons 4.0 (cc-by-nc) license, which allows the use of the work to share (copy and redistribute the material in any medium or format) and adapt (remix, transform and build from the material) as long as exclusive mention is made of the publication in the journal as a primary source, prohibiting its commercialization. The author always retains his/her right.