Mecanismos de acción hormonal a través de receptores ubicados en la membrana celular

Judith Pérez Avila, José Luis Valenciaga Rodríguez, Alina Acosta, Orlando Nicolau Mena, Silvia Elena Turcios Tristá, Francisco Navaroli Fernández

Texto completo:

PDF HTML

Resumen

Se realizó una revisión bibliográfica con el objetivo de exponer y analizar los mecanismos de acción hormonal a través de los receptores hormonales ubicados en la membrana celular, su estructura, la interacción Hormona – Receptor (H-R), los eventos que ocurren a partir de este momento, la participación de segundos mensajero, regulación de las transcripciones de la señal H-R dentro de la célula, su internalización y eventos finales del mecanismo de acción hormonal.

Palabras clave

hormonas; membrana celular

Referencias

Fagin JA. Genetic basis of endocrine disease 3: molecular defects in thyroid gland neoplasia. J Clin Endocrinol Metab 1992; 75:1398-400.

Hinkle PM. Introduction to cell signaling: introduction to molecular and cellular research. San Diego, California: The Endocrine Society; 1997.

Naruse M, Naruse K, Nishikawa T, Yoshihara I, Ohsumi K, Suzuki N, et al. Endothelin-3 immunoreactivity in gonadotrophy of the human anterior pituitary. J Clin Endocrinol Metab 1992; 74:968-972.

Mendez P, Azcoitia I, Garcia-Segura LM. Estrogen receptor alpha forms estrogendependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res Mol Brain Res 2003; 112(1-2):170-6.

Buckbinder L, Robinson RP. The glucocorticoid receptor: molecular mechanism and new therapeutic opportunities. Curr Drug Targets Inflamm Allergy 2002; 1(2):127-36.

Boyan BD, Dean DD, Sylvia VL, Schwartz Z. Steroid hormone action in musculoskeletal cells involves membrane receptor and nuclear receptor mechanisms. Connect Tissue Res 2003;44 Suppl 1:130-5.

Acconcia F, Marino M. Synergism between genomic and non genomic estrogen action mechanisms. IUBMB Life 2003; 55(3):145-50.

Ulloa-Aguirre A, Timossi C. Biochemical and functional aspects of gonadotrophin-releasing hormone and gonadotrophins. Reprod Biomed Online 2000;1(2):48-62.

Buckbinder L, Robinson RP. The glucocorticoid receptor: molecular mechanism and new therapeutic opportunities. Curr Drug Targets Inflamm Allergy 2002; 1(2):127-36.

Escriva Garcia H, Laudet V, Robinson-Rechavi M. Nuclear receptors are markers of animal genome evolution. J Struct Funct Genomics 2003;3(1-4):177-84.

Forsyth IA, Wallis M. Growth hormone and prolactin-molecular and functional evolution. J Mammary Gland Biol Neoplasia 2002; 7(3):291-312.

Chakraborty G, Reddy R, Drivas A, Ledeen RW. Interleukin-2 receptors and interleukin-2- mediated signaling in myelin: activation of diacylglycerol kinase and phosphatidylinositol 3- kinase. Neuroscience. 2003; 122(4):967-73.

Tamrazi A, Katzenellenbogen JA. Site-specific fluorescent labeling of estrogen receptors and structure-activity relationships of ligands in terms of receptor dimer stability. Methods Enzymol 2003; 364:37-53.

Maglich JM, Sluder AE, Willson TM, Moore JT. Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery. Am J Pharmacogenomics 2003; 3(5):345-53.

Joseph EK, Levine JD. Sexual dimorphism in the contribution of protein kinase C isoforms to nociception in the streptozotocin diabetic rat. Neuroscience. 2003; 120(4):907-13.

Grun F, Blumberg B. Identification of novel nuclear hormone receptor ligands by activityguided purification. Methods Enzymol 2003; 364:3-24.

Doughman RL, Firestone AJ, Wojtasiak ML, Bunce MW, Anderson RA. Membrane ruffling requires coordination between type I{alpha} phosphatidylinositol phosphate kinase and rac signaling. J Biol Chem 2003; 278(25):23036-45.

Ben-Chaim Y, Tour O, Dascal N, Parnas I, Parnas H. The M2 muscarinic G-protein-coupled receptor Is voltage-sensitive. J Biol Chem 2003; 278(25):22482-91.

Matre V, Hovring PI, Fjeldheim AK, Helgeland L, Orvain C, Andersson KB, Gautvik KM, Gabrielsen OS. The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-myb. Biochem J 2003; 372 (Pt 3):851-9.

Rhie DJ, Sung JH, Ha US, Kim HJ, Min DS, Hahn SJ, et al. Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells. Brain Res 2003; 975(1-2):120-8.

Vroemen SF, Van der Horst DJ, Van Marrewijk WJ. New insights into adipokinetic hormone signaling. Mol Cell Endocrinol 1998; 141(1-2):7-12.

Quondamatteo F. Assembly, stability and integrity of basement membranes in vivo. Histochem J 2002; 34(8-9):369-81.

Giannella RA, Mann EA. Escherichia coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions. Trans Am Clin Climatol Assoc 2003;114:67-85.

Alzamora R, Marusic ET, Gonzalez M, Michea L. Nongenomic effect of aldosterone on Na+, K+-adenosine triphosphatase in arterial vessels. Endocrinology. 2003; 144(4):1266-72.

Ritchie JW, Shi YB, Hayashi Y, Baird FE, Muchekehu RW, Christie GR, et al. A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors. Mol Endocrinol 2003; 17(4):653-61.

Ko L, Chin WW. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase. J Biol Chem 2003; 278(13):11471-9.

Secondo A, Sirabella R, Formisano L, D'Alessio A, Castaldo P, Amoroso S, et al. Involvement of PI3'-K, mitogen-activated protein kinase and protein kinase B in the upregulation of the expression of nNOSalpha and nNOSbeta splicing variants induced by PRL receptor activation in GH3 cells. J Neurochem 2003; 84(6):1367-77.

Vasilaki A, Georgoussi Z, Thermos K. Somatostatin receptors (sst2) are coupled to Go and modulate GTPase activity in the rabbit retina. J Neurochem 2000; 84(4):625-32.

Rupprecht R. Neuroactive steroids: mechanisms of action and

neuropsychopharmacological properties. Psychoneuroendocrinology. 2003; 28(2):139-68.

Shah BH, Soh JW, Catt KJ. Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation. J Biol Chem 2003; 278(5):2866-75.

Pedram A, Razandi M, Aitkenhead M, Hughes CC, Levin ER. Integration of the nongenomic and genomic actions of estrogen: membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem 2002;277(52):50768-75.

Guo YS, Cheng JZ, Jin GF, Gutkind JS, Hellmich MR, Townsend CM. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signalling pathways: evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J Biol Chem 2002; 277(50):48755-63.

Baumann G. Growth hormone binding protein: the soluble growth hormone receptor. Minerva Endocrinol 2002; 27(4):265-76.

Peluso JJ, Fernandez G, Pappalardo A, White BA. Membrane-initiated events account for progesterone's ability to regulate intracellular free calcium levels and inhibit rat granulosa cell mitosis. Biol Reprod 2002; 67(2):379-85.

Segars JH, Driggers PH. Estrogen action and cytoplasmic signaling cascades: part I: membrane-associated signaling complexes. Trends Endocrinol Metab 2002; 13(8):349-54.

Levin ER. Cellular functions of plasma membrane estrogen receptors. Steroids. 2002; 67 (6):471-5.

Kock CP de, Wierda KD, Bosman LW, Min R, Koksma JJ, Mansvelder HD, et al. Somatodendritic secretion in oxytocin neurons is upregulated during the female reproductive cycle. J Neurosci 2003; 23(7):2726-34.

Losel R, Feuring M, Wehling M. Non-genomic aldosterone action: from the cell membrane to human physiology. J Steroid Biochem Mol Biol 2002; 83(1-5):167-71.

Papaconstantinou AD, Umbreit TH, Goering PL, Brown KM. Effects of 17 alphamethyltestosterone on uterine morphology and heat shock protein expression are mediated through estrogen and androgen receptors. J Steroid Biochem Mol Biol 2002; 82(4-5):305-14.

Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev 2002; 23(5):665-86.

Heinlein CA, Chang CF. The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 2002;16(10):2181-7.

Enlaces refback

  • No hay ningún enlace refback.


Copyright (c) 2020 Judith Pérez Avila, José Luis Valenciaga Rodríguez, Alina Acosta, Orlando Nicolau Mena, Silvia Elena Turcios Tristá, Francisco Navaroli Fernández

Licencia de Creative Commons
Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.